Preheat oven to 400 degrees Fahrenheit and line a baking sheet with parchment paper.
In a large skillet over medium-high heat, brown the ground beef until no pink remains, breaking it into fine crumbles.
Drain the rendered fat from the skillet and stir in the salt, black pepper, onion powder, and garlic powder.
Lay a tortilla flat and distribute approximately 2.5 ounces of seasoned beef and 0.25 cups of shredded cheese across the center.
Roll the tortilla tightly and place it seam-side down on the prepared baking sheet.
Combine the melted butter, minced garlic, and parsley in a small bowl.
Brush the garlic butter mixture evenly over the top and sides of each rollup.
Bake for 12 to 15 minutes or until the tortillas achieve a golden brown color and crispy texture.
Allow to rest for 2 minutes before serving.