In a small bowl, whisk together Greek yogurt, mustard, ketchup, and pickle juice to create the sauce.
Heat a large non-stick skillet over medium-high heat.
Add ground beef to the skillet, breaking it apart with a spatula. Season with salt, pepper, garlic powder, and onion powder.
Cook until beef is browned and reaches an internal temperature of 160F (71C), approximately 8-10 minutes. Drain excess fat.
Divide shredded romaine lettuce between two bowls.
Top lettuce with equal portions of cooked ground beef.
Sprinkle shredded cheddar cheese over the hot beef to facilitate melting.
Garnish with cherry tomatoes, red onion, and pickles.
Drizzle the prepared sauce over the bowls and serve.