Heat a large skillet over medium-high heat.
Add the ground beef, salt, pepper, garlic powder, and onion powder to the skillet.
Cook the beef for 8 to 10 minutes, breaking it into small crumbles, until browned and cooked through. Drain excess fat if necessary.
In a small bowl, whisk together the Greek yogurt, mustard, ketchup, and pickle brine to create the protein-rich burger sauce.
Divide the shredded romaine lettuce among four individual serving bowls.
Top each lettuce base with the cooked beef, cherry tomatoes, red onion, and sliced pickles.
Evenly distribute the shredded cheddar cheese over the warm beef to allow it to melt slightly.
Drizzle the prepared sauce over each bowl and serve immediately.