Preheat oven to 375°F (190°C) and lightly grease a 9x13 inch baking dish.
Cook the high-protein pasta in a large pot of salted boiling water until 2 minutes before al dente; drain and set aside.
In a large mixing bowl, whisk together the blended cottage cheese, Greek yogurt, minced garlic, onion powder, red pepper flakes, salt, and black pepper.
Gradually stir the chicken broth into the yogurt mixture until a smooth sauce forms.
Add the cooked pasta, shredded chicken, squeezed spinach, and chopped artichokes to the bowl and toss until evenly coated.
Transfer the mixture into the prepared baking dish, pressing down slightly to level the surface.
Evenly distribute the shredded mozzarella and grated parmesan cheese over the top of the pasta.
Bake in the preheated oven for 25 minutes or until the cheese is melted and the edges are bubbling.
Remove from the oven and let the dish rest for 5 minutes to allow the sauce to set before serving.