Bring a large pot of salted water to a boil and cook the high-protein pasta according to package directions until al dente.
While pasta cooks, place a large skillet over medium-high heat and add the lean ground beef.
Cook the beef, breaking it into small crumbles with a spatula, until no pink remains (approximately 7 to 9 minutes).
Drain any excess liquid or fat from the skillet.
Add tomato paste, garlic powder, onion powder, paprika, salt, and pepper to the beef; stir and cook for 2 minutes to toast the spices.
Reduce the skillet heat to low to prevent the yogurt from curdling upon contact.
Whisk together the beef broth and Greek yogurt in a small bowl, then pour the mixture into the skillet with the beef.
Stir the sauce continuously until well combined and heated through, ensuring the mixture does not reach a boil.
Fold the cooked pasta and fresh baby spinach into the skillet.
Toss all ingredients together for approximately 2 minutes until the spinach is wilted and the pasta is thoroughly coated in the sauce.