Preheat the oven to 400°F (200°C) and line an 8-inch square baking dish with parchment paper.
In a medium bowl, combine cottage cheese, egg, parmesan cheese, Italian seasoning, and garlic powder.
Spread the cottage cheese mixture evenly into the bottom of the prepared baking dish.
Bake the base for 20 minutes until the edges are golden brown and the center is set.
Remove from the oven and spread the marinara sauce evenly over the baked cottage cheese base.
Top with shredded mozzarella cheese and pepperoni slices.
Return to the oven and bake for an additional 10 minutes, or until the cheese is melted and bubbly.
Allow the bake to rest for 5 minutes before slicing and serving.